We attempt to cover the questions that we were asked at the conference by the attendees, and we also expand on the content to some degree. Primarily, we wish to address the multitude of misconceptions and bad information that is floating around the ether when it comes to the proper use and capabilities of the various hemostatic agents out there. These misconceptions are enduring and prevalent in all circles, not just among laymen, but certainly also with professionals that frankly should know better. At the end of this article you will find a listing of studies, which really only represent a small sampling of the available information that is out there.
Now, something that we didn't touch upon in this video was the issue of debridement and the very common myth that using Quikclot - or really any hemostatic agent - significantly complicates the work that the surgical team will have to do when you get into the operating room to have your wound repaired. I ran into one fella here recently that insisted you should never use Quikclot on a gun shot wound... Wrap your head around that one, if you can.
While the first generation Quikclot granules did exhibit considerable tissue adhesion and a minor inflammatory response in the tissues that were in direct contact with the material, the reality of it is that ANY traumatic wound, whether it is sustained in a combat zone, a hunting accident, farm accident, or motor vehicle accident, is just not going to be this nice, clean cut that the surgeon can just stitch up and call it a day. On the contrary, traumatic injuries - especially the high-energy kind - are ragged, pulped messes that will require significant debridement of damaged and necrotic tissue before final repair can be achieved. Something that will often require multiple consecutive surgeries.
To further lay this myth to rest, there is of course also the fact that NONE of the current hemostatic agents available on the market - and I do mean current production, not stuff that will expire within the year - exhibit much in the way of issues with tissue necrosis and inflammation. Clean-up is as simple as irrigation and any debridement that is necessary is no more extensive than what would be needed if the wound hadn't been treated with a hemostatic agent. On the contrary, the chitosan hemostatics tend to exhibit less necrosis and inflammation than Kerlix gauze.
Again, as we mention in the video, all this information is readily available online. By all means, go research this for yourself, don't just take our word for it. The studies listed below will be a good start.
If there are any questions raised by this presentation, please feel free to ask them in the comment section. We will do our best to answer them, but fair warning; if common courtesy and civility isn't observed it will be simply deleted. We are all adults, so let us act like it.
Additional information can be found here: http://bfelabs.com/2012/10/28/hemostatic-agents-myths-lies-facts-applications/
Comparison of Celox-A, ChitoFlex, WoundStat, and Combat Gauze, etc. - http://bfelabs.files.
A New Hemostatic Agent: Initial Life-Saving Experience With Celox (Chitosan) in Cardiothoracic Surgery - http://bfelabs.files.
Novel Haemostatic Dressings - http://bfelabs.files.
Experience with Chitosan Hemostatic Dressings in Civillian EMS System - http://bfelabs.files.
A Complication of Intracorporeal Use of Quikclot for Pelvic Hemorrhage - http://bfelabs.files.
Celox (chitosan) for haemostasis in massive traumatic bleeding: experience in Afghanistan -http://bfelabs.files.
Comparative Testing of New Hemostatic Agents in Swine Model - http://bfelabs.files.
Journal of Prehospital Combat Casualty Care Apr/Jun 2011, containing Evaluation of Topical hemostatic Agents for Combat Wound Treatment - http://bfelabs.files.
Safety Evaluation of New Hemostatic Agents, Smectite Granules, and Kaolin-Coated Gauze in a Vascular Injury Wound Model in Swine - http://bfelabs.files.
Summary of Hemostatic Agent Studies revised - http://bfelabs.files.
QuikClot Use in Trauma for Hemorrhage Control: Case Series of 103 Documented Uses -http://bfelabs.files.
Biomaterials for Hemorrhage Control - http://bfelabs.files.
A Case Series Describing Thermal Injury Resulting from Zeolite Use etc. - http://bfelabs.files.
Survey of Current Hemostatic Agents - http://bfelabs.files.
Comparison of 10 hemostatic dressings in a groin puncture model in swine - http://bfelabs.files.
Hemostatic effect of a chitosan linear polymer (Celox) in a severe femoral artery bleeding rat model under hypothermia or warfarin therapy - http://bfelabs.files.
An Alternative Hemostatic Dressing: Comparison of CELOX, HemCon, and QuikClot -http://bfelabs.files.
A New Hemostatic Agent: Initial Life-Saving Experience With Celox (Chitosan) in Cardiothoracic Surgery - http://bfelabs.files.
Novel Haemostatic Dressings - http://bfelabs.files.
Experience with Chitosan Hemostatic Dressings in Civillian EMS System - http://bfelabs.files.
A Complication of Intracorporeal Use of Quikclot for Pelvic Hemorrhage - http://bfelabs.files.
Celox (chitosan) for haemostasis in massive traumatic bleeding: experience in Afghanistan -http://bfelabs.files.
Comparative Testing of New Hemostatic Agents in Swine Model - http://bfelabs.files.
Journal of Prehospital Combat Casualty Care Apr/Jun 2011, containing Evaluation of Topical hemostatic Agents for Combat Wound Treatment - http://bfelabs.files.
Safety Evaluation of New Hemostatic Agents, Smectite Granules, and Kaolin-Coated Gauze in a Vascular Injury Wound Model in Swine - http://bfelabs.files.
Summary of Hemostatic Agent Studies revised - http://bfelabs.files.
QuikClot Use in Trauma for Hemorrhage Control: Case Series of 103 Documented Uses -http://bfelabs.files.
Biomaterials for Hemorrhage Control - http://bfelabs.files.
A Case Series Describing Thermal Injury Resulting from Zeolite Use etc. - http://bfelabs.files.
Survey of Current Hemostatic Agents - http://bfelabs.files.
Comparison of 10 hemostatic dressings in a groin puncture model in swine - http://bfelabs.files.
Hemostatic effect of a chitosan linear polymer (Celox) in a severe femoral artery bleeding rat model under hypothermia or warfarin therapy - http://bfelabs.files.
An Alternative Hemostatic Dressing: Comparison of CELOX, HemCon, and QuikClot -http://bfelabs.files.
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